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Former surgeon general Dr. Vivek Murthy says that underlying many of the most critical public health issues facing America today is an epidemic of loneliness. NPR's Michel Martin speaks with Dr. Murthy about what that means, and what he thinks should be done about it.

President Trump is expected to refuse to meet a deadline for endorsing the U.S. participation in the Iran nuclear deal. It doesn't take the U.S. out of the deal, but it sends the issue to Congress and could rattle U.S. allies.

NPR's Lulu Garcia-Navarro and Will Shortz, New York Times crossword editor and Weekend Edition's Puzzle Master, play this week's puzzle with Phil Jacknis of Dix Hills, N.Y.

Bria Vinaite landed the role after director Sean Baker discovered her on Instagram. "It was my first time reading a script," she says, "and it made me cry the first time I read it."

Agnes Varda practically invented the French New Wave, and at 89 she's still working, co-directing a new film with artist JR about their travels through the French countryside in his photography van.

The Hollywood mogul has been fired by the board of the film studio he co-founded, following recent reports of allegations that he sexual harassed females for decades.

One of the victims of the Las Vegas shooting was 16-year-old Nick Campbell. Shot in the shoulder, he threw himself on his girlfriend to protect her. He recounts the experience and concludes, "I'll stay the same," he says.

These days everyone has a political podcast. Lulu Garcia-Navarro talks with podcasters Michael Graham and Emily Bazelon, who review some of the new political podcasts on the left and right.

Police in Bangladesh announced that at least 12 people have died after a boat capsized. It had been carrying Rohingya Muslims fleeing Myanmar.

The Swedish Academy said it was awarding Thaler the prize in economics for his pioneering work in incorporating "psychologically realistic assumptions into analyses of economic decision-making."